A phenomenological computational model of the evoked action potential fitted to human cochlear implant responses.

There is a growing interest in biomedical engineering in developing procedures that provide accurate simulations of the neural response to electrical stimulus produced by implants. Moreover, recent research focuses on models that take into account individual patient characteristics. We present a phenomenological computational model that is customized with the patient's data provided by the electrically evoked compound action potential (ECAP) for simulating the neural response to electrical stimulus produced by the electrodes of cochlear implants (CIs). The model links the input currents of the electrodes to the simulated ECAP. Potentials and currents are calculated by solving the quasi-static approximation of the Maxwell equations with the finite element method (FEM). In ECAPs recording, an active electrode generates a current that elicits action potentials in the surrounding auditory nerve fibers (ANFs). The sum of these action potentials is registered by other nearby electrode. Our computational model emulates this phenomenon introducing a set of line current sources replacing the ANFs by a set of virtual neurons (VNs). To fit the ECAP amplitudes we assign a suitable weight to each VN related with the probability of an ANF to be excited. This probability is expressed by a cumulative beta distribution parameterized by two shape parameters that are calculated by means of a differential evolution algorithm (DE). Being the weights function of the current density, any change in the design of the CI affecting the current density produces changes in the weights and, therefore, in the simulated ECAP, which confers to our model a predictive capacity. The results of the validation with ECAP data from two patients are presented, achieving a satisfactory fit of the experimental data with those provided by the proposed computational model.

An Approach to Multi-Objective Path Planning Optimization for Underwater Gliders.

Underwater gliders are energy-efficient vehicles that rely on changes in buoyancy in order to convert up and down movement into forward displacement. These vehicles are conceived as multi-sensor platforms, and can be used to collect ocean data for long periods in wide range areas. This endurance is achieved at the cost of low speed, which requires extensive planning to ensure vehicle safety and mission success, particularly when dealing with strong ocean currents. As gliders are often involved on missions that pursue multiple objectives (track events, reach a target point, avoid obstacles, sample specified areas, save energy), path planning requires a way to deal with several constraints at the same time; this makes glider path planning a multi-objective (MO) optimization problem. In this work, we analyse the usage of the non-dominated sorting genetic algorithm II (NSGA-II) to tackle a MO glider path planning application on a complex environment integrating 3D and time varying ocean currents. Multiple experiments using a glider kinematic simulator coupled with NSGA-II, combining different control parameters were carried out, to find the best parameter configuration that provided suitable paths for the desired mission. Ultimately, the system described in this work was able to optimize multi-objective trajectories, providing non dominated solutions. Such a planning tool could be of great interest in real mission planning, to assist glider pilots in selecting the most convenient paths for the vehicle, taking into account ocean forecasts and particular characteristics of the deployment location.

A multiobjective optimization procedure for the electrode design of cochlear implants.

This paper presents a new procedure to design optimal electrodes for cochlear implants. The main objective of this study is to find a set of electrode designs that maximize the focalization and minimize the power consumption simultaneously. To achieve that, a criterion to measure the ability of focalization of an electrode is proposed. It is presented a procedure to determine (1) the electrical potential induced by an electrode by solving the Laplace equation through the finite element method; (2) the response of a neuron to an applied field using NEURON, a compartmentalized cell model; (3) the optimization to find the best electrode designs according to power consumption and focalization by 2 evolutionary multiobjective methods based on the non-dominated sorting genetic algorithm II: a straight multiobjective approach and a seeded multiobjective approach. An electrode design formed by 2 conductive rings with a possible difference of potential between them is proposed. It is analyzed that the response of the neuron is determined by the shape and the difference of the potential between the electrode rings. Our procedure successfully achieves a nondominated set of optimum electrode designs improving a standard electrode in both objectives, as designs with better focalization allow to include extra electrodes in the cochlear implant, and designs with lower power consumption extend the length of the battery.